The Expedite 8909 allows synthesis scale ranges from 50 nmol to 15 µmol for DNA oligonucleotides. This system allows preparation of phosphorothioates and enables preparation of peptide nucleic acid (PNA) molecules, which contain neutral "peptidelike" backbones with nucleobases. The 8909 comes with sequence and
protocol editors. Cycle times are 3.5 minutes for both single and dual column synthesis. With alternating phase synthesis, the two columns function essentially as independent units. You can start and stop an individual synthesis without influencing the progress of the other column. You can even run different scales and synthesis protocols simultaneously on the two columns. The Expedite 8909 allows synthesis scale ranges from 50 nmol to 15 µmol for DNA
oligonucleotides. This system allows preparation of phosphorothioates and peptide nucleic acid (PNA) molecules, which contain neutral "peptide-like" backbones with nucleobases. The built-in trityl monitor, a standard feature on the 8909 model, contains a LED detector that reads the absorbance of the released dimethoxytrityl fractions to indicate the success of the synthesis – in real-time. If the absorbance falls below a pre-set value, the synthesis is put on hold. Prior to synthesis, systems are automatically checked for correct operation. Low pressure gas blankets reagent reservoirs to maintain an anhydrous environment, and high pressure gas actuates the injectors. The Expedite™ Systems check for leaks and adequate pressure to ensure that if the gas is depleted the synthesis is not affected.